Ukrainian State Medical University, M.D.(with Honors), 1994; University of Dusseldorf, Germany, Postdoctoral, 1995-1996; University of North Carolina at Chapel Hill, Ph.D., 2000; University of North Carolina at Chapel Hill, Postdoctoral, 2000-2001; Massachusetts Institute of Technology, Postdoctoral, 2001-2002
Molecular Carcinogenesis, Liver, Toxicology, Genomics, Cancer
Relevant Experience:
Dr. Rusyn's laboratory has an active research portfolio of several R01s and components in program-project like grants with a focus on oxidative DNA damage and repair, nuclear receptor-mediated pathways in chemical carcinogenesis, the role that alcohol and diet play in cancer, and the genetic determinants of the susceptibility to toxicant-induced organ injury. Dr. Rusyn maintains close ties with researchers in japan and Ukraine. He co-organized international scientific meetings in the US and abroad (Ukraine). He tought his toxicology course in the Institute of Ecohygiene and Toxicology in Kiev, Ukraine in 2007.
Distinctions:
1994 First Class Honors Diploma, Ukrainian State Medical University, Kiev, Ukraine; 1995-1996 Research Fellowship, German Academic Exchange Service (DAAD); 1998/99/2001 Young Investigator Award, Oxygen Society; 2000 Young Investigator Award, Soc. for Free Radical Research International; 2000 AACR - Bristol Myers Squibb Oncology Young Investigator Scholar Award; 2000 Carl C. Smith Mechanisms Specialty Section Award, Society of Toxicology; 2000 Visiting Professor of Surgery, Yamanashi Medical University, Japan; 2000-2001 Leon & Bertha Golberg Memorial Postdoctoral Fellowship, UNC-Chapel Hill; 2000-2002 Individual Postdoctoral National Research Service Award, NIEHS; 2002-2005 Transition to Independent Position Award, NIEHS
Dissertations and Theses Supervised in Past 5 Years:
5
Relevant Courses Taught:
ENVR442/TOXC442: Biochemical and Molecular Toxicology; ENVR722/TOXC722: Toxicology Seminar
Recent Publications:
• 2008 Zhu, H., Rusyn, I., Richard, A., and Tropsha A. (2008)
The use of cell viability assay data improves the prediction accuracy of conventional quantitative structure activity relationship models of animal carcinogenicity.
Envr Health Persp.
• 2007 Gatti, D., Maki, A., Chesler, E.J., Kirova, R., Lu, L., Wang, J., Williams, R.W., Perkins, A., Langston, M.A., Threadgill, D.W., and Rusyn, I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557, 2007.
• 2007 Maki, A., Kono, H., Gupta, M., Asakawa, M., Suzuki, T., Matsuda, M., Fujii, H., and Rusyn, I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14:1182-90, 2007.
• 2006 Rusyn, I., Peters, J.M., and Cunningham, M.L. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol 36:459-479, 2006.
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