Pharmacokinetics, Drug Transport, Hepatic Drug Disposition
Relevant Experience:
Dissertations and Theses Supervised in Past 5 Years:
8
Relevant Courses Taught:
Recent Publications:
• 2008 Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, Brouwer KL. "Relationship between drug/metabolite exposure and impairment of excretory transport function." Drug Metab Dispos. 2009 Feb;37(2):386-90. Epub 2008 Nov 20.
• 2007 Leslie, E.M., Watkins, P.B., Kim, R.B. and Brouwer K.L.R.: Differential Inhibition of Rat and Human Na+-Dependent Taurocholate Cotransporting Polypeptide (NTCP/SLC10A1) by Bosentan: A Mechanism for Species Differences in Hepatotoxicity. J. Pharmacol. Exp. Ther. 321:1170-1178, 2007.
• 2007 Bow DA, Perry JL, Miller DS, Pritchard JB, Brouwer KL. "Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes." Drug Metab Dispos. 2008 Jan;36(1):198-202. Epub 2007 Oct 22.
• 2007 Ghibellini, G., Bridges, A.S., Generaux, C.N and Brouwer K.L.R.: In Vitro and In Vivo Determination of Piperacillin Metabolism in Humans. Drug Metab. Dispos. 35:345-349, 2007.
• 2007 Tian, X., Li, J., Zamek-Gliszczynski, M.J., Bridges, A.S., Zhang, P., Patel, N.J., Raub, T.J., Pollack, G.M. and Brouwer K.L.R.: The Roles of P-gp, Bcrp and Mrp2 in the Biliary Excretion of Spiramycin in Mice. Antimicrob. Agents Chemother. 51:3230-3234, 2007.
• 2007 Ghibellini, G., Vasist, L.S., Leslie, E.M., Heizer, W.D., Kowalsky, R.J., Calvo, B.F. and Brouwer, K.L.R.: In Vitro-In Vivo Correlation of Hepatobiliary Drug Clearance in Humans. Clin. Pharmacol. Ther. 81:406-413, 2007.
• 2006 Zamek-Gliszczynski, M.J., Nezasa, K., Tian, X., Bridges, A.S., Lee, K., Belinsky, M.G., Kruh, G.D. and Brouwer, K.L.R.: Evaluation of the Role of Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 in Hepatic Basolateral Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Abcc3(-/-) and Abcc4(-/-) Mice. J. Pharmacol. Exp. Ther. 319:1485-1491, 2006.
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