John Sealy Distinguished University Chair, UNC-CH
Professor, Departments of Microbiology & Immunology and Internal Medicine,
UNC-CH
Director, Institute for Human Infections and Immunity, UNC-CH
• MD Doctor of Medicine with Honor, University of Rochester 1972
World Area Of Focus:
• Asia 10%-24%
Specialization:
Interested in the innate immune responses to RNA viruses, and how these viruses have evolved to escape these host defenses. Our research focuses on the molecular pathogenesis of hepatitis C virus (HCV) - related liver diseases, including in particular HCV-associated hepatocellular carcinoma, and the development of effective therapies for hepatitis C.
Relevant Experience:
• Overseas experience in Japan
Distinctions:
• -ongoing Meritorious Service Medal United States Army (4 November 1983)
Kenan Research Leave The University of North Carolina at Chapel Hill (1989-1990)
Commissioner's Special Citation U.S. Food and Drug Administration (May 10, 1996)
Recent Publications:
• 2017 An Efficient, Large-Scale Survey of Hepatitis C Viremia in the Democratic Republic of the Congo Using Dried Blood Spots. Parr JB, Lodge EK, Holzmayer V, Pepin J, Frost EH, Fried MW, McGivern DR, Lemon SM, Keeler C, Emch M, Mwandagalirwa K, Tshefu A, Fwamba F, Muwonga J, Meshnick SR, Cloherty G. Clin Infect Dis. 2017 Oct 18. doi: 10.1093/cid/cix771. [Epub ahead of print]
• 2017 The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis. Lanford RE, Walker CM, Lemon SM. ILAR J. 2017 Oct 17:1-18. doi: 10.1093/ilar/ilx028. [Epub ahead of print]
• 2017 NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR. Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM. Nat Immunol. 2017 Oct 2. doi: 10.1038/ni.3853. [Epub ahead of print]
• 2017 Type A viral hepatitis: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention. Lemon SM, Ott JJ, Van Damme P, Shouval D. J Hepatol. 2017 Sep 5. pii: S0168-8278(17)32278-X. doi: 10.1016/j.jhep.2017.08.034. [Epub ahead of print] Review.
• 2017 TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions. Das A, Hirai-Yuki A, González-López O, Rhein B, Moller-Tank S, Brouillette R, Hensley L, Misumi I, Lovell W, Cullen JM, Whitmire JK, Maury W, Lemon SM. MBio. 2017 Sep 5;8(5). pii: e00969-17. doi: 10.1128/mBio.00969-17.
• 2017 Three-dimensional Fusion Imaging without Contrast Medium for Carotid Endarterectomy. Matsumoto M, Mizutani T, Sumi K, Shimizu K. J Neurol Surg A Cent Eur Neurosurg. 2017 Nov 1. doi: 10.1055/s-0037-1607226. [Epub ahead of print] No abstract available.
• 2017 Significance of Computed Tomography and Serum Potassium in Predicting Subtype Diagnosis of Primary Aldosteronism. Umakoshi H, Tsuiki M, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Yanase T, Suzuki T, Naruse M; JPAS Study Group.
• 2017 Characterization of redundant tRNAIles with CAU and UAU anticodons in Lactobacillus plantarum. Tomikawa C, Auxilien S, Guérineau V, Yoshioka Y, Miyoshi K, Hori H, Fourmy D, Takai K, Yoshizawa S. J Biochem. 2017 Oct 30. doi: 10.1093/jb/mvx075. [Epub ahead of print]
• 2017 The regulation mechanisms of AhR by molecular chaperone complex. Kudo I, Hosaka M, Haga A, Tsuji N, Nagata Y, Okada H, Fukuda K, Kakizaki Y, Okamoto T, Grave E, Itoh H. J Biochem. 2017 Oct 28. doi: 10.1093/jb/mvx074. [Epub ahead of print]
• 2014 Co-immunoprecipitation of Flag-TLR3 or Myc-MSR1 with HCV RNA. Yamane D, Dansako H, Lemon SM. Bio Protoc. 2014 Feb 20;4(4). pii: e1061. doi: 10.21769/BioProtoc.1061.
• 2006 Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats (S.M. LEMON and D. Relman, Committee Co-Chairs), Globalization, Biosecurity, and the Future of the Life Sciences. National Academy Press, Washington, DC.
• 2006 S.L.Knobler, T. Burroughs, A. Mahmoud, S.M. Lemon (eds.), Ensuring an Infectious Disease Workforce: Education and Training needs for the 21st Century. National Academy Press, Washington, DC.
• 2005 S.L. Knobler, A. Mack, A. Mahmoud, S.M. LEMON (eds.), The Threat of Pandemic Influenza: Are We Ready? National Academy Press, Washington, D.C., 2005. .M. Lemon, M.D. Page - 10
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