L. Dykstra's laboratory focuses on the behavioral pharmacology of opioid analgesics, both in relation to their pain-relieving properties as well as their tendency to produce tolerance and dependence. A more recent research interest is the investigation of behavioral phenotypes related to substance abuse in genetically altered mice.
Relevant Experience:
Dean of the Graduate School; Research focus on Drugs of Abuse, with continuous funding from the National Institute on Drug Abuse since 1977
Distinctions:
William Rand Kenan Jr. Distinguished Professor; Research Career Development Award (NIH); Research Scientist Award (NIH); MERIT award(NIH); President of the College on Problems of Drug Dependence; Mentorship Award; President of the Psychopharmacology Division of the American Psychological Association; President, Association of Graduate Schools; Chair of the Behavioral Pharmacology Division of the American Society of Pharmacology and Experimental Therapeutics Vice-President/President of the North Carolina Association of Biomedical Research.
Dissertations and Theses Supervised in Past 5 Years:
4
Relevant Courses Taught:
Drugs and Human Behavior Behavioral Pharmacology
Recent Publications:
• 2016 Green, J.L., Dykstra, L.A., Carelli, R.M. (2015) Examination of cocaine dose in a preclinical model of natural reward devaluation by cocaine. Behav Pharmacol. 26 (4): 398-402. PMID: 25738759 [PubMed - in process]: PMC4409927
• 2014 Balter, R.E. & Dykstra, L.A. (2013) Thermal sensitivity as a measure of spontaneous morphine withdrawal in mice. J Pharmacol Toxicol Methods 67: 162-168 PMID 23416790
• 2008 Miller, L.L., Ward, S.J. and Dykstra, L.A. Behavioral Pharmacology 19: 575-581, 2008.
• 2008 Fischer, B.D., Zimmerman, E.I., Picker, M.J. and Dykstra, L.A. (2008) Morphine in combination with metabotropic glutmate receptor antagonists on schedule-controlled responding and thermal nociception. Journal of Pharmacology and Experimental Therapeutics, 324: 732-739
• 2007 Allen, R.M., Dykstra, L.A. and Carelli, R.M. (2007) Continuous exposure to a competitive NMDA receptor antagonists facilitates escalation of cocaine consumption in rats. Psychopharmaology 191: 341-351
• 2007 Ward, S.J. and Dykstra,L.A. (2007) Attenuation of cue-induced reinstatement of ensure but not corn oil seeking by the cannabinoid CB1 antagonists, SR 141716A and CB1 knockout in mice. Neuropsychopharm
• 2006 Fischer, B.D. and Dykstra, L.A. (2006) Interactions between an NMDA antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception. J. Pharmacol. Exp. There. 318: 1300-1306
• 2005 Medvedev, I.O., Bohn, L.M., Gainetdinov, R.R., Caron, M.G. and Dykstra, L.A.(2005)Characterization of conditioned place preference to cocaine in isogenic dopamine transporter knockout mice. Psychopharmacology 180: 408-413, 2005
• 2005 Allen, R.M., Carelli, R.M., Dykstra, L.A., Suchey, T.L., Everett, C.V. (2005) Effects of the competittive NMDA receptor antaognists, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959), on responding for cocaine under both fixed and progressive ratio scheudles of reinforcement. J. Pharmacol. Exp. Ther. 315: 449-457
• 2005 Fischer, B.D., Carrigan, K.A. and Dykstra, L.A. (2005) Effects of N-methyl-D-aspartate receptor antagonists on acute morphine- and l-methadone-induced antinociception in mice. J. Pain 6: 425-433
• 2005 Ward, S. J. & Dykstra, L. A. (2005). The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940). Behav.Pharmacol, 16, 381-388.
• 2004 Carroll, F.I., Thomas, J.B., Dykstra, L.A., Granger, A.L., Allen, R.M., Howard, J.L., Pollard, G.T., Aceto, M.D. and Harris, L.S. (2004) Pharmacological properties of JDTic: A novel k opioid receptor antaognist. Eur. J. Pharmacol. 501: 111-119
• 2003 Bohn, L.M., Gainetdinov, R.R., Stonikova, T.D., Lefkowitz, R.J., Dykstra, L.A. and Caron, M.G. (2003) Enhanced rewarding properties of morphine, but not cocaine, in barrestin-2 knockout mice. J. Neurosci. 23: 10265-10273
Searches are not case-sensitive.
Enclosing two or more words in double quotes will return
only faculty profiles containing the quoted terms in the
requested order (e.g. a search for "Public Health" will
only return faculty profiles that contain the phrase
'Public Health'.)
Use 'AND' in keyword box to search for words that appear
in any order in a faculty profile (e.g. a search for
'Public AND Health' will return faculty profiles that
contain both the individual words 'Public' and
'Health.')
Using 'OR' in keyword box will broaden your search by
returning faculty profiles that contain keywords on
either side of the word 'OR' (e.g. a search for 'Public
OR Health' will return faculty profiles that contain
either one or both of the words 'Public' and 'Health.' )
A shortened form of your keyword will further broaden
your search (e.g. a search for 'demo' will return
faculty profiles that contain words begin with 'demo,'
such as 'demographic', 'democratic'.)
If search terms are entered without quotes, they are
treated as if a logical 'OR' was placed between each
term. For example, a search for 'Public Health Malaysia'
will return faculty profiles that contain the individual
words 'Public' and/or 'Health' and/or 'Malaysia.'
Quickly enter the first few letters of the faculty last name.
Select the faculty name you are searching for from the
result list.
