ࡱ> AC>?@{ {bjbjBrBr 1  :@668tPT6 4!!!!v_"$"$]8"!!""8!!Mm@m@m@"*!!m@"m@m@!8BNc00j@j\ ""m@"""""88m@""""""""""""""""6 V:  CURRICULUM VITAE Personal Information: Name: Benjamin F Calvo, M.D. Office Address: University of North Carolina at Chapel Hill Dept. of Surgery / Division of Surgical Oncology 1150 Physicians Office Building 170 Manning Drive, CB#7213 Chapel Hill, NC 27599 Clinical Investigation: UNC Hospitals The University of North Carolina at Chapel Hill 101 Manning Drive Chapel Hill, NC 27599-7600 Phone: Work: (919) 966-5221 Fax: (919) 966-8806 E-mail  HYPERLINK "mailto:calvo@med.unc.edu" calvo@med.unc.edu Education: 8/1977-6/1981 Maryland University School of Medicine, Baltimore, Maryland Degree: Doctor of Medicine 8/1973-6/1977 George Washington University, Washington, DC Bachelor of Science with Distinction: Majors in Chemistry and Zoology 8/1971-6/1973 Winston Churchill High School, Maryland, USA 8/1968-6/1971 American Cooperative School, La Paz, Bolivia 8/1961-6/1968 Colegio San Ignacio, La Paz, Bolivia Post Doctoral Training: 07/1991-06/1993 Fellow, Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 07/1987-06/1991 Research Fellow, National Cancer Institute (NIH-NCI) Laboratory of Tumor Immunology and Biology, Bethesda, MD 07/1987-06/1988 Chief Resident, Dept. of Surgery, George Washington University Hospital, Washington, DC 07/1985-06/1986 Completed course work for Ph.D. Field of Study in Immunology George Washington University, Washington, DC 07/1982 -06/1987 General Surgery Resident, Dept. of Surgery, George Washington University Hospital, Washington, DC 7/1981-6/1982 Medical Director of Boat Clinic Mamore and Itenez Rivers, Amazon Basin, Bolivia Faculty Appointments 07/2009-present Chief, Division of Surgical Oncology and Endocrine Surgery, The University of North Carolina, Chapel Hill. 09/2000- present Associate Professor of Surgery, Division of Surgical Oncology and Endocrine Surgery, The University of North Carolina, Chapel Hill. 09/1993- 08/2000 Assistant Professor of Surgery, Section of Surgical Oncology The University of North Carolina, Chapel Hill. Board Certification: 2010-2021 Recertification Certificate #35687 Recertification Certificate #35687 1991-2001 Diplomate of American Board of Surgery, Certificate #35687 Licensure: 1993-present North Carolina (#93-00430) 1991-1995 New York (#185663-1) 1982-1993 District of Columbia (# 000033529) Special Honors and Awards: 2011 Best Surgical Oncology Doctors of North America 2010 Castle Connollys Americas Top Doctors 2009 Best Surgical Oncology Doctors of North America 2008 Teacher of the Year. Presented by the Chief Surgery Residents. University of North Carolina at Chapel Hill 2008 Best Surgical Oncology Doctors of North America 2006 Surgical Service of the Year: Surgical Oncology 2006 Best Surgical Oncology Doctors of North America 2003 Teacher of the Year. Presented by the Chief Surgery Residents. University of North Carolina at Chapel Hill 2002 Surgical Service of the Year: Surgical Oncology 2002-present James F. Newsome, M.D. Endowed Term Professor in Surgical Oncology, University of North Carolina-Chapel Hill 2000 Surgical Service of the Year: Surgical Oncology (First Annual Award). 1998 Teacher of the Year. Presented by the Chief Surgery Residents. University of North Carolina at Chapel Hill 1987 The Outstanding Surgical Chief Resident: The George Washington University Hospital. 1977 Phi Beta Kappa. The George Washington University. 1976 French National Honor Society, The George Washington University. 1973-1977 Varsity Soccer four years. The George Washington University. NCAA Playoffs 1976 Bibliography: Book Chapters: Abrams, J., Cance, W.G., Calvo, B.F.: Parathyroid Adenoma and Carcinoma. In: Unbound Surgery. Pappas (ed.) 2004. Refereed Journals: Llaguna OH, Kim HJ, Deal AM, Calvo BF, Stitzenberg KB, Meyers MO. Utilization and morbidity associated with placement of a feeding jejunostomy at the time of gastroesophageal resection. J Gastrointest Surg. 2011 Oct;15(10):1663-9. Epub 2011 Jul 28. PubMed PMID: 21796458 Davies JM, Trembath D, Deal AM, Funkhouser WK, Calvo BF, Finnegan T, Weck KE, Tepper JE, O'Neil BH. Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy. Radiat Oncol. 2011 Sep 12;6:114. PubMed PMID: 21910869 Llaguna OH, Calvo BF, Stitzenberg KB, Deal AM, Burke CT, Dixon RG, Stavas JM, Meyers MO. Utilization of interventional radiology in the postoperative management of patients after surgery for locally advanced and recurrent rectal cancer. Am Surg. 2011 Aug;77(8):1086-90. PubMed PMID: 21944529. Llaguna OH, Desai P, Fender AB, Zedek DC, Meyers MO, O'Neil BH, Diaz LA, Calvo BF.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/21113348" Subcutaneous Metastatic Adenocarcinoma: An Unusual Presentation of Colon Cancer - Case Report and Literature Review. Case Rep Oncol. 2010 Oct 27;3(3):386-390. O'Neil BH, Funkhouser WK, Calvo BF, Meyers MO, Kim HJ, Goldberg RM, Bernard SA, Caskey L, Deal AM, Wright F, Baldwin AS, Tepper JE. Nuclear Factor kappa-light Chail-Enhancer of Ativated B Cells is Activated by Radiotherapy and is prognostic for Overall Survival in Patients with rectal Cancer Treated with Preoperative Fluorouracil-based Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2010 Jul 12. [Epub ahead of print Stratford JK, Bentrem DJ, Anderson JM, Fan C, Volmar KA, Marron JS, Routh ED, Caskey LS, Samuel JC, Der CJ, Thorne LB, Calvo BF, Kim HJ, Talamonti MS, Iacobuzio-Donahue CA, Hollingsworth MA, Perou CM, Yeh JJ A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med. 2010 Jul 13;7(7):e1000307. PubMed PMID: 20644708; PubMed Central PMCID: PMC2903589 Charles S Hultman, MD, MBA; Matthew A Sherrill, MD; Eric G Halvorson, MD; Clara N Lee, MD, MPP; John F Boggess, MD; Michael O Meyers, MD; Benjamin A Calvo, MD; Hong J Kim, MD Utility of the omentum in pelvic floor reconstruction following resection of anorectal malignancy: Patient selection, technical caveats, and clinical outcomes. Ann. Plastic Surgery 2010 May; 64(5):559-62. (PMID 20395804) ONeil BH, Raftery L, Calvo BF, Chakravathi AB, Ivanova A, Meyers MO, Kim HJ, Chan E, Wise PE, Caskey LS, Bernard SA, Sanoff HK, Goldberg RM, and Tepper JE. A phase I study of bortezomib in combination with standard 5-fluorouracil and external beam radiotherapy for the treatment of locally advanced or metastatic rectal cancer. Clin Colorectal Cancer. 9(2):119-125, April 2010 (PMID 20378507)  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Kimple%20RJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Kimple RJ,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Vaseva%20AV%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Vaseva AV,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Cox%20AD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Cox AD,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Baerman%20KM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Baerman KM,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Calvo%20BF%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Calvo BF,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Tepper%20JE%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Tepper JE,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Shields%20JM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Shields JM,  HYPERLINK "http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed?term=%22Sartor%20CI%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract" Sartor CI. Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clin. Cancer Res. 2010 Feb 1;16(3):912-23. Epub 2010 Jan 26. Meyers MO, Russell CP, Ollila DW, Yeh JJ, Kim HJ, Calvo BF. Postoperative hypocalcemia after parathroidectomy in the era of cinacalcet. Am Surg. 2009 Sep;75(9):843-7 Caudle AS, Kim HJ, Tepper JE, O'Neil BH, Lange LA, Goldberg RM, Bernard SA, Calvo BF, Meyers MO. Diabetes mellitus affects response to neoadjuvant chemoradiotherapy in the management of rectal cancer. Ann Surg Oncol. 2008 Jul;15(7):1931-6. Epub 2008 Apr 17. Amin C, Wallen E, Pruthi RS, Calvo BF, Godley PA, Rathmell WK Preoperative tyrosine kinase inhibition as an adjunct to debulking nephrectomy. 2008 Oct;72(4):864-8. Epub 2008 Aug 5. Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, Krop IE, Kelley MC, Arteaga CL. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J Clin Oncol. 2008 Feb 20; 26(6):897-906. Epub 2008 Jan 7. Khandani AH, Calvo BF, O'Neil BH, Jorgenson J, Mauro MA. A pilot study of early 18F-FDG PET to evaluate the effectiveness of radiofrequency ablation of liver metastases. AJR Am J Roentgenol. 2007 Nov 189(5):1199-202.  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17119868&query_hl=8&itool=pubmed_docsum" Caudle AS, Tepper JE, Calvo BF, Meyers MO, Goyal LK, Cance WG, Kim HJ. Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas. Ann Surg Oncol. 2007 Feb;14(2):577-82  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17235333&query_hl=8&itool=pubmed_docsum" Ghibellini G, Vasist LS, Leslie EM, Heizer WD, Kowalsky RJ, Calvo BF, Brouwer KL. In vitro-in vivo correlation of hepatobiliary drug clearance in humans. Clin Pharmacol Ther. 2007 Mar; 81(3):406-13. Epub 2007 Jan 18  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17235715&query_hl=8&itool=pubmed_docsum" Stitzenberg KB, Klauber-Demore N, Chang XS, Calvo BF, Ollila DW, Goyal LK, Meyers MO, Kim HJ, Tepper JE, Sartor CI. In Vivo Intraoperative Radiotherapy: A Novel Approach to Radiotherapy for Early Stage Breast Cancer. Ann Surg Oncol. 2007 Jan 18 Caudle AS, Brier SE, Calvo BF, Kim HJ, Meyers MO, Ollila DW. Experienced radio-guided surgery teams can successfully perform minimally invasive radio-guided parathyroidectomy without intraoperative parathyroid hormone assays. Am Surg. 2006 Sep;72(9):785-9  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16720159&query_hl=8&itool=pubmed_docsum" Neuman H, Carey LA, Ollila DW, Livasy C, Calvo BF, Meyer AA, Kim HJ, Meyers MO, Dees EC, Collichio FA, Sartor CI, Moore DT, Sawyer LR, Frank J, Klauber-DeMore N.Axillary lymph node count is lower after neoadjuvant chemotherapy. Am J Surg. 2006 Jun;191(6):827-9  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16523367&query_hl=8&itool=pubmed_docsum" Klauber-DeMore N, Ollila DW, Moore DT, Livasy C, Calvo BF, Kim HJ, Dees EC, Sartor CI, Sawyer LR, Graham M 2nd, Carey LA.Size of residual lymph node metastasis after neoadjuvant chemotherapy in locally advanced breast cancer patients is prognostic. Ann Surg Oncol. 2006 May; 13(5):685-91. Ollila DW, Caudle AS, Cance WG, Kim HJ, Cusack JC, Swasey JE, Calvo BF. Successful minimally invasive parathyroidectomy for primary hyperparathyroidism without using intraoperative parathyroid hormone assays. Am J Surg. 2006 Jan;191(1):52-6 Klauber-Demore N, Calvo BF, Hultman CS, Kim HJ, Meyers MO, Damitz L, Frank JS, Stitzenberg KB, Sartor CI, Ollila DW. Staged sentinel lymph node biopsy before mastectomy facilitates surgical planning for breast cancer patients. Am J Surg. 2005 Oct;190(4):595-7.  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15788665" Hatch SB, Lightfoot HM Jr, Garwacki CP, Moore DT, Calvo BF, Woosley JT, Sciarrotta J, Funkhouser WK, Farber RA.Microsatellite Instability Testing in Colorectal Carcinoma: Choice of Markers Affects Sensitivity of Detection of Mismatch-Repair-Deficient Tumors. Clin Cancer Res. 2005 Mar 15;11(6):2180-7. Klauber-DeMore, N, Ogunrinde, OB, Kuzmiak, C, Rager, E, , Ollila, D, Calvo, B, Kim, HJ, Dees, C, Graham, M, Collichio, F, Sartor, C, Metzger, R, Carey, LA. High-Resolution Axillary Ultrasound is a Poor Prognostic test for Determining Pathologic lymph Node Status in Patients Undergoing Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer. Am. J. Surgery. 2004 Oct; 188(4):386-9. Stitzenberg KB, Meyer AA, Stern SL, Cance WG, Calvo BF, Klauber-DeMore N, Kim HJ, Sansbury L, Ollila DW. Extracapsular extension of the sentinel lymph node metastasis: a predictor of nonsentinel node tumor burden. Annals of Surgery. 2003 May;237(5):607-12; discussion 612-3 Earp HS 3rd, Calvo BF, Sartor CI. The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. Trans Am Clin Climatol Assoc. 2003;114:315-33; discussion 333-4. Review Poole ME, Bernard SA, Churchel MA, Weissler MC, Calvo B, Cance W, Ollila D, Koruda M, Behrns K, Detterbeck FC: A phase I study of gemcitabine and docetaxel for advanced stage solid tumors. Cancer Invest. 2003 Jun;21(3):350-4 Amy L. Lark, Chad A. Livasy, Benjamin Calvo, Laura Caskey, Dominic T. Moore, XiHui Yang, and William G. Cance: Overexpression of Focal Adhesion Kinase in Primary Colorectal Carcinomas and Colorectal Liver Metastases: Immunohistochemistry and Real-Time PCR Analyses. Clinical Cancer Research 9: 215-222, 2003. Benjamin F. Calvo, Aaron M. Levine, Mavie Marcos, Qu F. Collins, Mary V. Iacocca, Laura S. Caskey, Christopher W. Gregory, Yuhua Lin, Young E. Whang, H. Shelton Earp, and James L. Mohler: Human Epidermal Receptor-2 Expression in Prostate Cancer Clinical Cancer Research. 9: 1087-1097. 2003. Hultman CS, Damitz L, Daiza S, Ollila D, Klauber-Demore N, Cance W, Calvo B, Kim HJ, and Meyer AA. Skin-sparing mastectomy flap complications following breast reconstruction: incidence, risk factors, and effect on adjuvant therapies. Plastic Surgical Forum, 2002. Cance WG, Carey LA, Calvo BF, Sartor C, Sawyer L, Moore DT, Rosenman J, Ollila DW, Graham M 2nd. Long-term outcome of neoadjuvant therapy for locally advanced breast carcinoma: effective clinical downstaging allows breast preservation and predicts outstanding local control and survival. Annals of Surgery. 2002 Sep;236(3):295-302; discussion 302-3 Hultman, C.S., Damitz, L., Daiza, S., Ollila, D., Klauber-DeMore, N., Cance, W., Calvo, B., Kim, HJ, Meyer, A.A: Skin-sparing mastectomy flap complications following breast reconstruction: Incidence, risk factors, and effect on adjuvant therapies. Plastic Surgical Forum 2002, XXV:225-226. Stitzenberg, K.B., Calvo, B.F., Iacocca, M.V., Neelon, B.H., Sansbury, L.B., Dressler, L.G., Ollila, D.W.: Cytokeratin immunohistochemical vaildation of the sentinel node hypothesis in patients with breast cancer. American Journal of Clinical Pathology. 117(5):729-37, 2002. Kim, K.S., Baek, S.J., Flake, G.P., Loftin, C.D., Calvo, B.F., Eling, T.E.: Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology. 122(5):1388-98, 2002. Kang, J.S., Calvo, B.F., Maygarden, S.J., Caskey, L.S., Mohler, J.L., and Ornstein, D.K.: Dysregulation of Annexin I Protein Expression in High-Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer. Clinical Cancer Research. 8:117-123, 2002 Sartor, C. I., Zhou, H., Kozlowska, E., Guttridge, K., Kawata, E., Caskey, L., Harrelson, J., Hynes, N., Ethier, S., Calvo, B., and Earp, H. S., 3rd: Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. Molecular & Cellular Biology. 21:4265-75, 2001. Bieligk, S.C., Calvo, B.F., Coit, D.G.: Peritoneovenous Shunting for Non-Gynecologic Malignant Ascites. Cancer. 91(7):1247-1255, 2000. Amjadi, D, Calvo, B, Dressler, L, Iacocca, M.: Sentinel lymphadenectomy: immunohistologic validation and improved axillary staging for breast carcinoma: the Chapel Hill experience. American Journal of Clininical Pathathology. 112:538-539, 1999. Ikawa, H., Kamitani, H., Calvo, B.F., Foley, J.F., and Eling, T.E.: Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer. Cancer Research. 59:360-366, 1999. Calvo, B.F. and Semelka, R.C.: Beyond Anatomy, MRI as a Molecular Diagnostic Tool. Surgical Oncology Clinics of North America, Scott H. Kurtzman (ed.). 8(1):171-183, January 1999. Worawattanakul, S., Semelka, R.C., Noone, T.C., Calvo, B.F., Kelekis, N.L., Woosley, J.T.: Cholangiocarcinoma: spectrum of appearances on MR images using current techniques. Magnetic Resonance Imaging. 16(9):993-1003, 1998. Sofka, C. M., Semelka, R. C., Marcos, H. B., Calvo, B. F., and Woosley, J. T.: Metastatic gastric leiomyoblastoma: a case report. Magnetic Resonance Imaging. 16:343-6, 1998. Yu, H., Li, X., Marchetto, G. S., Dy, R., Hunter, D., Calvo, B., Dawson, T. L., Wilm, M., Anderegg, R. J., Graves, L. M., and Earp, H. S.: Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. Journal of Biological Chemistry. 271:29993-8, 1996. Semelka, R. C., Kelekis, N. L., Molina, P. L., Sharp, T. J., and Calvo, B.: Pancreatic masses with inconclusive findings on spiral CT: is there a role for MRI? Journal of Magnetic Resonance Imaging. 6:585-8, 1996. Slavin-Chiorini, D. C., Kashmiri, S. V., Schlom, J., Calvo, B., Shu, L. M., Schott, M. E., Milenic, D. E., Snoy, P., Carrasquillo, J., Anderson, K., and et al.: Biological properties of chimeric domain-deleted anticarcinoma immunoglobulins. Cancer Research. 55:5957s-5967s, 1995. Scanlan, M. J., Raj, B. K., Calvo, B., Garin-Chesa, P., Sanz-Moncasi, M. P., Healey, J. H., Old, L. J., and Rettig, W. J.: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proceedings of the National Academy of Sciences of the United States of America. 91:5657-61, 1994. Abergel, C., Padlan, E. A., Kashmiri, S. V., Milenic, D., Calvo, B., and Schlom, J.: Crystallographic studies and primary structure of the antitumor monoclonal CC49 Fab'. Proteins. 17:438-43, 1993. Tsang KY, Kashmiri SV, DeFilippi R, Qi CF, Calvo B, Shu L, Nieroda CA, Greiner JW, Schlom J.: A human T cell line engineered to secrete chimeric monoclonal antibody. Journal of Immunotherapy. 13(3):143-52, 1993. Slavin-Chiorini, D. C., Horan Hand, P. H., Kashmiri, S. V., Calvo, B., Zaremba, S., and Schlom, J.: Biologic properties of a CH2 domain-deleted recombinant immunoglobulin. International Journal of Cancer. 53:97-103, 1993. Tsang, K. Y., Kashmiri, S. V., Qi, C. F., Nieroda, C., Calvo, B., De Filippi, R., Greiner, J. W., Primus, F. J., and Schlom, J.: Transfer of the IL-6 gene into a human colorectal carcinoma cell line and consequent enhancement of tumor antigen expression. Immunology Letters. 36:179-85, 1993. Marquez E, Calvo. B., Brennan M.: Manejo de los Sarcomas de partes blandas en las extremidades y retroperitoneo. Centro Medico. 39:1-8, 1993. Calvo, B., Kashmiri, S. V., Hutzell, P., Hand, P. H., Slavin-Chiorini, D. C., Schlom, J., and Zaremba, S.: Construction and purification of domain-deleted immunoglobulin variants of the recombinant/chimeric B72.3 (y1) monoclonal antibody. Cancer Biotherapy. 8:95-109, 1993. Hand, P. H., Calvo, B., Milenic, D., Yokota, T., Finch, M., Snoy, P., Garmestani, K., Gansow, O., Schlom, J., and Kashmiri, S. V.: Comparative biological properties of a recombinant chimeric anti-carcinoma mAb and a recombinant aglycosylated variant. Cancer Immunology, Immunotherapy. 35:165-74, 1992. Tsang K, Kashmiri SVS, Masci AM, Primus FJ, Finch M, Calvo BF, Schlom J: Generation of novel variants of an anti-colon carcinoma monoclonal antibody by heavy chain transduction into a light chain producing cell line. Cancer Immunology Immunotherapy. 34:9-16, 1991. Casscells, W., Speir, E., Sasse, J., Klagsbrun, M., Allen, P., Lee, M., Calvo, B., Chiba, M., Haggroth, L., Folkman, J., and et al.: Isolation, characterization, and localization of heparin-binding growth factors in the heart. Journal of Clinical Investigation. 85:433-41, 1990. Published Poster Presentations: A multidisciplinary approach using intraoperative electron radiation therapy improves local control in retroperitoneal sarcoma. Sweeting RS, Llaguna OH, Bednarski BK, Meyers MO,Yeh JJ, Deal AM, Tepper JE, Calvo BF, Kim HJ. Society of Surgical Oncology 65th Annual Cancer Symposium, Orlando, FL, March 21-24, 2012. KRAS mutation is a poor prognostic factor in patients undergoing hepatic resection for metastatic colorectal cancer. Aufforth RD, Baker JJ, Auman J, Eil R, McLeod H, Kim HJ, Meyers MO, Calvo BF, Yeh JJ. Society of Surgical Oncology 65th Annual Cancer Symposium, Orlando, FL, March 21-24, 2012. Oncologic outcomes following radical resection with intraoperative electron radiation therapy (IOERT) in patients with locally advanced recurrent rectal cancer. Omar H. Llaguna, Michael O. Meyers, Matthew B. Smith, Karyn B. Stitzenberg, Allison M. Deal, Richard M. Goldberg, Stephen A. Bernard, Bert H. ONeil, Andrew Z. Wang, Joel E. Tepper, Benjamin F. Calvo. ASCO Gastrointestinal Cancers Symposium, San Francisco. January 21, 2011 Relationship between K-Ras status with pAKT, pERK and outcomes in patients with rectal cancer. J.M Davies, D Trembath, A.M Deal, W.K. Funkhouser, B.F. Calvo, T.J. Finnegan, K. Weck, J.E Tepper, B.H. ONeil; ASCO Gastrointestinal Cancers Symposium, Orlando Fla. January 23, 2010 Pancreatic Cancer Radiosensitization by Nelfinavir Randall J. Kimple1, Angelina V. Vaseva, Adrienne D. Cox, Kathryn M. Baerman, Benjamin F. Calvo, Joel E. Tepper, Janiel Shields, and Carolyn I. Sartor. ASTRO meeting 2008 A Pilot Study of early PET to evaluate the effectiveness of radiofrequency ablation of liver metasases. AH Khandani, BF Calvo, BH ONeil, J Jorgenson, MA Mauro. SNM 2007 Annual Meeting: Abstract #1657 Colorectal tumors show increased amphiregulin expression. Caudle AS, Rubinas TC, Caskey LS, Earp HS, Calvo BF Gastrointestinal Cancers Symposium, January 19, 2007 Early gene expression response to radiation in patients with rectal cancer: B.H. ONeil, B.F. Calvo, L.Caskey, D. Threadgill, F. Wright, J.Jin, H. Kim, M. Meyers, J.E. Tepper, D.I Sartor. (poster) Gastrointestinal Cancers Symposium, January 19, 2007 Diabetes decreases response to neoadjuvant therapy in rectal cancer. Caudle AS, Calvo BF, Kim HJ, Bernard S, Tepper JE, ONeil BH, Meyers MO. Poster Presentation. Society of Surgical Oncology (March 2006) Changes in NF-kappa B-Related Gene Expression and Global Gene Expression Induced by Therapeutic Radiation in Rectal Adenocarcinoma ONeil BH, Calvo BF, Hawke NA, Kim HJ, Meyers M, Burns N, Threadgill DW, Caskey L, Tepper JE, Goldberg RM, Bernard SA, Baldwin AS, and Sartor CI. GI-SPORE Investigators Workshop, Washington DC. July 2005. Brubaker L, Stitzenberg KB, Kim HJ, Meyers MO, Ollila DW, Goyal LK, Calvo BF, Tepper JE. Incorporating intraoperative radiotherapy into the multimodality treatment of locally-advanced rectal cancer using a mobile accelerator. Society of Surgical Oncology, Atlanta, Georgia, March 4, 2005. (poster) EGFR/HER2 targeted therapy inhibits growth of pancreatic cancer cells K.M Baerman, L.S> Caskey, F. Dasi, H.S. Earp, B. F. Calvo. Society of Surgical Oncology. Atlanta, Georgia, March 2-6, 2005 Neoadjuvant chemotherapy is associated with a lower lymph node count in patients undergoing axillary lymph node dissection. Neuman, H., Ollila D.W., Carey, L.A., Calvo, B.F., Meyer, A., Kim, H.J., Meyers, M., Dees, C.E., Collichio, F.A, Sartor, c., Sawyer, L.R., Graham, M., Klauber-DeMore, N Breast Cancer Research and Treatment, Vol. 88:S79, 2004 High-Resolution Axillary Ultrasound is a Poor Prognostic test for Determining Pathologic lymph Node Status in Patients Undergoing Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer. Klauber-DeMore, N, Ogunrinde, OB, Kuzmiak, C, Rager, E, , Ollila, D, Calvo, B, Kim, HJ, Dees, C, Graham, M, Collichio, F, Sartor, C, Metzger, R, Carey, LA.. The American Society of Breast Surgeons 5th Annual Meeting, April 2, 2004 Differential sensitivity of colon cancer cell lines to ErbB kinase inhibitors. Francisco Dasi, Laura Caskey, H.Shelton Earp III, Benjamin Calvo. AACR 95th Annual Meeting Proceedings, Volume 45: Abstract 4409. March 2004. Colorectal Adenocarcinomas express increased message levels of HER2 and HER3. B. F. Calvo, L. S. Caskey, D. Moore, H. S. Earp, P. B. Paty ASCO Gastro Intestinal Malignancies Symposium, San Francisco Jan 2004. Real-Time Fluorescent Quantitative PCR reveals increased Her2, Her3 and unchanged Her1 (EGFR) mRNA expression levels in colorectal carcinomas. B Calvo, L Caskey, HS Earp. Poster #536 AACR-NCI-EORTC International Conference. AACR Molecular Targets and Cancer Therapeutics Meeting, Miami, FL, November 2001. The Epidermal Growth Factor Receptor variant III truncated receptor mRNA is not detected in Breast or Prostate Carcinomas. B Calvo, L Caskey, C Sartor, Z Hong, K Guttridge, HS Earp. Lineberger Comprehensive Cancer Center1 and Dept. of Surgery 2 at the University of North Carolina at Chapel Hill, 9th Spore Investigators Workshop, July 15, 2001. Expression of the Epidermal Growth Factor Receptor Variant (EGFRvIII) in a Normal Human Breast Epithelial Cell Line Induces Growth Factor Independence, Constitutive Activation of Dowstream Signal Transduction Pathways and Soft Agar Growth. CI Sartor, H Zhou, B Calvo, K Guttridge, R Dy, HS Earp. AACR Annual Meeting, New Orleans, LA, 2001. Proceedings of AACR, Vol 42, March 2001. Differences in Expression Profiles of Epidermal Growth Factor Receptors (HER1-4) in Beast and Prostate Carcinomas. BF Calvo, LS Caskey, C Sartor, J Mohler, HS Earp. AACR Annual Meeting, New Orleans, LA, 2001. Proceedings of AACR, Vol 42, March 2001. Predictors of Nonsentinel Node Metastasis in Breast Cancer Patients: Size and Extracapsular Extension of the Sentinel Node Metastasis. KB Stitzenberg, BF Calvo, BH Neelon, MV Iacocca, DW Ollila. 23rd Annual San Antonio Breast Cancer Symposium, December 6-9, 2000. A Role of HER-4 in Differentiation of Human Breast Cancer Cells. C Sartor, B Calvo, H Zhou, L Caskey, E Koslowska, K Guttridge, HS Earp. 8th Spore Investigators Workshop, July, 10, 2000. Time and Dose-Intense Neoadjuvant Therapy for Locally Advanced Breast Carcinoma. LA Carey, WG Cance, P Gonzalez, BF Calvo, ML Graham. Proc. ASCO, Vol.19:153A Abstract 608, 2000. Sentinel Node Metastasis With Extracapsular Extension Can Predict Risk Of Nonsentinel Node Involvement In Breast Cancer Patients. DW Ollila, KB Stitzenberg, MV Iacocca, BF Calvo. Society of Surgical Oncology, New Orleans, LA, March 16-18, 2000. Sentinel Lymphadenectomy: Immunohistologic validation and improved axillary staging for breast carcinoma: The Chapel Hill experience. D Amjadi, JD, B Calvo, L Dressler, M Iacocca. The Departments of Pathology and Laboratory Medicine, and Surgery, and The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina. ASCP Meeting, 1999. Long-Term outcome for dose-dense sequential Doxorubicin (A) and IV CMF (A.CMF) with G-CSF (G) support as part of time-dense multi-modality therapy for high risk stage II and III breast cancer. M Graham, W Cance, P Gonzalez, B Calvo, J Halle, J Rosenman. Meeting of the American Society of Clinical Oncology, 1999. Proc. ASCO 18:95a, 1999 (abstract 357). Peritoneovenous shunting for Non-Gynecologic Malignant Ascites. SC Bieligk, B Calvo, DG Coit. Meeting of the Society of Surgical Oncology, Memorial Sloan-Kettering Cancer Center, 1997. Oral Presentations Epiregulin, one of the HER-Family Ligands, As Well As HER-Family-Receptors HER2 And HER3 Are Overexpressed In Gastric Adenocarcinoma. M. B. Smith, M. O. Meyers, L. S. Caskey, H. S. Earp, B. F. Calvo. 6th Annual Academic Surgical Congress: Association for Academic Surgery. Huntington Beach, California February 3, 2011 1- The EGFR receptor family in solid malignancies. 2- Intra Operative Electron Therapy for advanced and recurrent rectal carcinoma. 3- Novel Technologies in the treatment of hepatic metastases from colorectal carcinomas. XX Congress of the Latin American Federation of Cancer Societes, FLASCA 2010, Santa Cruz, Bolivia November 10-13, 2010 HYPERLINK "http://www.FLASCA2010.COM/"WWW.FLASCA2010.COM invited. The Treatment of Recurrent Rectal Cancer and Integration of Intra-Operative Electron Radiation Therapy (IOERT) Meeting of the Society of Pelvic Floor Surgery. Durham North Carolina Sept 17, 2010 invited. Rectal Cancer Surgery: Pre-op Imaging Scans and Endorectal Ultrasound Colorectal cancer and Liver metastases for the Community Surgeon. Society of Surgical Oncology 63rd Annual Cancer Symposium. St. Louis, MO. March 3, 2010 invited. Epiregulin mRNA expression in colorectal hepatic metastases is associated with survival post partial hepatectomy. M.B. Smith, A.S. Caudle, L.S. Caskey, M.O. Meyers, D.T Moore, B.F. Calvo. Cancer Forum II. Society of Surgical Oncology 63rd Annual Cancer Symposium. St. Louis, MO. March 3, 2010 The surgery of thyroid cancer. 49th Annual Meeting of the Southeastern Chapter Society of Nuclear Medicine. Clearwater Beach, Florida. September 26, 2008 invited. Key topics in the surgical management of rectal cancer. 8th Annual Perspectives in Colorectal Cancer. Affiliated with the World Congress on Gastrointestinal Cancer. Miami, Florida September 7-8, 2007 invited. Decrease of Local Recurrences with Intraoperative Radiotherapy for Rectal Cancer. Karyn B Stitzenberg, Lauren Brubaker, Michael O. Meyers, Hong Jin Kim, Joel E. Tepper, Benjamin F. Calvo. Second International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico February 2007. Increased amphiregulin expression in colorectal tumors may explain clinical response to cetuximab Caudle AS, Rubinas TC, Caskey LS, Earp HS, Calvo BF 14th SPORE investigators Workshop. Baltimore, Maryland Experienced Radio-Guided Surgery Teams Can Successfully Perform Minimally Invasive Parathyroidectomy Without Intraoperative Parathyroid Hormone Assays.Caudle AS, Ollila DW, Kim HJ, Meyers MO, Swasey JE, Calvo BF. Oral Presentation. Southeastern Surgical Congress. (February 2006) Radiosensitization of pancreas cancer cell lines by the dual EGFR/HER2 inhibitor, lapatinib.Angelina Vaseva, Ben Calvo, Adrienne Cox, Carolyn Sartor. AACR/Lustgarten Pancreas Carcinoma Meeting June 26-27 in Chapel Hill, N.C. Stitzenberg KB, Meyers MO, Kim HJ, Tepper JE, Ollila DW, Goyal LK, Calvo BF. Intraoperative radiotherapy for locally-advanced primary and recurrent rectal cancer. American College of Surgeons Clinical Congress Video Education Sessions, San Francisco, California, October 19, 2005. (podium/video) In Vivo Intraoperative Radiotherapy: A Novel Approach to Breast Radiotherapy for Early Stage Breast Cancer. Karyn B. Stitzenberg, Nancy Klauber-DeMore, Benjamin F. Calvo, Lav K. Goyal, David W. Ollila, Michael O. Meyers, Hong Jin Kim, Joel E. Tepper, and Carolyn I. Sartor. Society of Surgical Oncology, Atlanta,GA, March, 2005. (podium presentation ) Staged Sentinel Lymph Node Biopsy Prior to Mastectomy Facilitates Surgical Planning for Breast Cancer Patients. Klauber-DeMore, N., Calvo, B., Kim, H.J., Meyers, M., Hultman, C., Damitz, L., Frank, J., Sartor, C., Ollila, D.W. The American Society of Breast Surgeons 6th Annual Meeting, March 18, 2005. (presentation) EGFR/HER2 targeted therapy inhibits growth of pancreatic cancer cells. K.M Baerman, L.S Halsey, F. Dasi, H.S. Earp, B.F. Calvo. Gastro Intestinal Cancer Symposium (Hollywood Florida) Oral Presentation, Abstract No:84 January 28, 2005. Bloqueo de la familia de receptores HER1-4 en cancer colorrectal: Hacia un conocimiento mas profundo . : Dasi F; Caskey L; Lledo S; Earp HS; Calvo BF. Congreso Nacional de Cirugia (Madrid). Oral Presentation Abstract No: 1185. November 10, 2004 invited. Extracapsular extension and size of the sentinel lymph node metastasis: predictors of nonsentinel node tumor burden. Stitzenberg KB, Meyer A, Cance WG, Calvo BF, Klauber-DeMore N, Kim HJ, Sansbury L, Ollila DW:. 104th Annual Session of the Southern Surgical Association, Palm Beach, FL, December 1, 2002 Skin-sparing mastectomy flap complications following breast reconstruction: Incidence, risk factors, and effect on adjuvant therapies. CS Hultman, L Damitz, S Daiza, D Ollila, N Klauber-DeMore, W Cance, B Calvo, HJ Kim, AA Meyer. 71st Annual Scientific Meeting of the American Society of Plastic Surgeons, San Antonio, TX, November 2-6, 2002 TXS, Plastic Surgical Forum XXV:225-226, 2002. Long-term outcome of neoadjuvant therapy for advanced breast carcinoma: Effective clinical downstating allows breast preservation and predicts outstanding local control and survival. WG Cance, LA Carey, BF Calvo, L Sawyer, J Rosenman, M Graham, II. American Surgical Association, 2002. DNA Mismatch Repair Protein Expression and Microsatellite Instability in Sporadic Colorectal Cancer Patients from North Carolina. SB Hatch, HM Lightfoot, BF Calvo, CP Garwacki, JT Woosley, WK Funkhouser, RA. Farber. Curriculum in Genetics and Molecular Biology, Dept. of Pathology and Laboratory Medicine, Dept. of Surgery and Lineberger Comprehensive Cancer Center, Univ. of North Carolina, Chapel Hill, NC. AACR Annual Meeting 2002 Geographic variations in sphincter-Sparing surgery rates in the treatment of rectal cancer. DD Morris, BH Neelon, BF Qaqish, MJ Schell, JE Tepper, BF Calvo. Annual Meeting of the American Society of Clinical Oncology, 1999. Instituto Oncologico del Oriente, Santa Cruz, Bolivia, Update Course Aspectos Basicos de la Colo-Proctologia. Sphincter preservation for rectal cancer. Surgical treatment of Hepatic metastases. October 13-17, 1999 invited. Panels: Prevention, Diagnosis and Treatment of Colorectal Cancer for Hispanic-Americans Yearly Bi-National Conference UNC CELAH Center for Latino Health October 1, 2012 invited. Colorectal metastases and Intrahepatic Cholangiocarcinomas. 23rd Annual Fall Foliage Conference, Asheville North Carolina. October 21, 2011 invited. Basic knowledge about colorectal cancer for Hispanic-Americans Yearly Bi-National Conference October 6, 2011 invited. Recent surgical advances in colorectal cancer Colorectal Cancer Evidence Academy Western North Carolina AHEC, Lake Junaluska NC. March 12, 2010 invited. Role of Surgery in Metastatic Disease New Developments in Cancer Care: 2009 Year in Review Wake AHEC, Raleigh North Carolina Dec 5,2009 invited. Hepatic resection of colorectal metastases with extrahepatic Disease, Debate Second Annual Multimodality GI Oncology Conference, Winston-Salem North Carolina June 19, 2009 invited. Multidisciplinary Management of Colorectal Liver metastases Meeting of the North Carolina Surgical Society, Wilmington North Carolina December 6, 2007 invited. Persistent/Recurrent Carcinoma of the Rectum. Meeting of the North Carolina Surgical Association, Virginia, Sept 29, 2007 invited. Surgical Treatment of Advanced and Metastatic colorectal Cancer. North Carolina Comprehensive Cancer Program. Greensboro June 9,2007 invited. 6. Meeting Moderator Surgical Forum - Surgical Oncology III: American College of Surgeons Clinical Congress, New Orleans, October 13, 2004. 7. Multidisciplinary Cancer Management: Interactive Tumor Board Discussion of Gastrointestinal Stromal Tumor (GIST). American College of Surgeons Clinical Congress October 11, 2004 invited. 8. 1-Use of Intraoperative Radiation Therapy in the treatment of Recurrent and advanced rectal cancer. 2- Directions in research and multidisciplinary care of rectal cancer. Meeting of the Latin American Society of Colo-Proctology, Santa Cruz, Bolivia July 2004 invited. 9. Cellular, Molecular, and Tumor Biology Minisymposium 97. Channing J. Der Chair, Benjamin F. Calvo Co-Chair. AACR 95th Annual Meeting. Orlando Fla, March 2004. 9. EGFR Receptor Family blockade in Colorectal Cancer.Meeting: Glaxo Smith Kline Symposium. Research Triangle Park, November 11, 2003 invited. 10. Annual Meeting Director North Carolina Chapter of the American College of Surgeons Annual Meeting. Grove Park Inn July 2003 11. Surgical Forum - Surgical Oncolgy II. Moderator Meeting: American College of Surgeons Clinical Congress, San Francisco, October 9, 2002 invited. 12. 1- Use of MRI and PET in staging of colorectal carcinomas, 2- Resection of Hepatic Metastases and Intra-Arterial Chemotherapy, 3- Early Data on Sentinel Nodes for Colorectal Carcinoma Meeting: 5th Bolivian Congress of Colo- Proctology, Santa Cruz, Bolivia, April3-5, 2001 invited. 13. Currents in the surgical treatment of carcinomas and sarcomas- reasons for hope. Meeting: 6th Annual Mini-Medical School Program, University of North Carolina at Chapel Hill, March 20,, 2001. 14. The Role of Epidermal Growth Factor Receptors in Colo-rectal Carcinoma. Meeting: 4th Ibero-American Congress of Colo-Proctology and the Spanish Association of Colo-proctology, Marbella, Spain, November 23, 2000 invited. 15. Current Therapies and Future Directions in the Treatment of Colorectal Cancers. Meeting: Primary Care Management of Common Gastrointestinal Disorders, UNC School of Nursing, Chapel Hill, October 26, 2000. 16. 1- Surgical Treatment of Hepatic Metastases 2- Adjuvant and Neoadjuvant Therapy in Rectal Cancer 3- Genetic predisposition to Colon Cancer 4- Genetics and Cancer, The next Decade Meeting: Bolivian National Surgical Congress, Santa Cruz, Bolivia, August 28-30, 2000 invited. 17. Loco-regional therapeutic alternatives for hepatic metastases for colorectal carcinoma, Meeting Co-Director Meeting: Management of Locally Advanced Rectal Cancer and Metastatic Colorectal Cancer. American College of Surgeons North Carolina Chapter, November 18, 1999. Instituto Oncologico del Oriente, Santa Cruz, Bolivia, Update Course Aspectos Basicos de la Colo-Proctologia. Sphincter preservation for rectal cancer. Surgical treatment of hepatic metastases. October 13-17, 1999 invited. 18. Sentinel Lymph Node Biopsy in Breast Cancer Patients: UNC Validation Trial. Meeting: Thirtieth Anniversary Biennial Meeting of the Nathan A. Womack Surgical Society, University of North Carolina at Chapel Hill, May 6, 1999 19. From Nevus to Metastatic Disease: Complete Care of the Melanoma Patient at UNC, Lineberger Comprehensive Cancer Center Board of Visitors meeting, June 6, 1999. 20. Update on Sphincter Preservation for Rectal Cancer. Meeting: American College of Surgeons North Carolina Chapter Annual Cancer Symposium, Duke University, November 14, 1997 invited. 21. Topic: Screening for Colo-rectal Neoplasms. Meeting: Fifth Annual Coastal Oncology Symposium, Wilmington, NC, October 4, 1997 invited. 22. Surgical Treatment of Melanoma Panel on Diagnosis, Staging and Treatment of Melanoma, May 1997. 23. Section on Cancer Treatment and Control - Moderator. Meeting: North Carolina Cancer Research Symposium- National Institutes of Environmental Health Sciences, February 16, 1996 invited. 24. Surgical Therapy of Hepatic Metastases. Meeting: Treatment Modalities in Colorectal Cancer. American College of Surgeons North Carolina Chapter, November 9, 1995 invited. 25. Genetic Screening for Colorectal Malignancies. Meeting: American College of Surgeons North Carolina Chapter, Asheville Meeting, July 1995 invited. 26. Treatment of Locally Advanced Breast Cancer.Meeting: American College of Surgeons North Carolina Chapter - Symposium on Breast Cancer Diagnosis and Treatment, November, 1994 invited. 27. Molecular Markers for Early Detection and Treatment of Cancer Meeting: American Cancer Society Meeting, Atlanta, Georgia, October, 1994 invited. Teaching responsibilitis: Lectures Graduate School: 2010-present GYN Oncology Fellows Conference. January, 2010 Treatment of Ovarian Carcinoma hepatic metastases 2004-present Cancer Pathobiology Course (Pathology 225) Lecture 1 - ErbB family of receptors and ligands in solid malignancies. Lecture 2- Surgical Principles for Solid Malignancies Medical Students: 2012-present MSIII Surgical Rotation (every 8 weeks) Neck Masses, Differentia Diagnosis and Treatment 2010- 2011 MS IV Integration Selective Course The EGFR receptor and ligand families in the treatment of epithelial malignancies. Jan-12-2010, July 26, 2010 2000- 2011 MSIII Lectures, Gastro-Intestinal malignancies (Every other 8 week rotation on Surgery) 1995-1999 Research project preceptor for one medical student every July-September through The Cancer Education Program. Residents: 1998-Present Surgical Oncology Resident Serivice Conference (Every Friday 7:00- 8:00AM) Discussion of following weeks planed operations. Laparoscopic Course for Residents. Laparoscopic and Open Ultrasound usage. Radio Frequency Ablation Techniques September 2002 1994-2002 Multidisciplinary Breast Cancer Conference every Wednesday 12:15- 1:30 PM 1994-present Multidisciplinary GI and Sarcoma Conference every Monday Morning 7:30-8:30 AM 1994-2000 Surgical Resident Lecture Series (Monday afternoons). Various topics including: Colo-rectal Malignancies, Gastric Malignances, Adrenal Neoplasms, Melanoma, Breast Neoplasms. 1994-2000 Surgical Resident Journal Club (selected Saturday mornings). Papers covering breast disease, melanoma, sarcoma, GI malignancies and endocrine topics. 1994-2000 Basic Surgical Education Lecture to Interns, Molecular Biology in Cancer Diagnosis and Treatment Once a year. 1997 Conception and organization of course for residents (invited national lecturers and animal laboratory) on Sonography for the Surgeon, Sentinel Lymph Node Biopsies and Laparoscopic Techniques. 1999-2005 Palliative Care Course, yearly lecture on Palliative Surgical Therapy for Cancer Patients. 2006, 2005, 2002, 1995, 1993 Attending staff participant in Resident as Teacher Symposium Clinical Teaching: Grand Rounds Presentations University of North Carolina Dept. of Surgery: 12-09-09 The Many Faces of Tumor Ablation 01/28/09 International Surgery, What does it mean? 10/4/06 Epidermal Growth Factor Receptor Family and its Application in Cancer Therapy 01/20/04 Research Directions in Surgical Oncology 6/06/01 Rectal Cancer Treatment - Present State, Future Directions 05/31/01 Her1-4 Growth Factor Receptors in Solid Malignancies 10/18/00 Overview of Cancer Genetics 6/28/99 The Epidermal Growth Factor Receptor Family in Breast Cancer: Potpourri of Signals 7/98 Novel Therapeutics in Treatment of Cancer 4/22/98 National Trends in Rectal Cancer Management 1997 Sentinel Lymph Nodes: Old Ideas, New Horizons 8/24/95 Genetic Screening for Colorectal Malignancies 9/28/94 Update of Active CALGB Oncology Protocols: Solid Malignancies 8/24/94 Monoclonal Antibodies in the Treatment of Solid Malignancies s 11/10/93 Pancreatic Cancer: Its Second component Conference Presentations UNC Other Departments: 09/23/04 GI Research Conference Effects of EGFR family receptor inhibition in Pancreatic Cancer 09/20/03 GI Research Conference. The EGFR family in colorectal cancer. Effects of inhibitors in cell line models 01/23/02 UNC Anesthesiology Service Rounds Present and Future of Intra Operative Radiation Therapy 9/20/00 UNC Dermatology Service Conference. Update on Multidisciplinary Melanoma Care 8/23/99 UNC Dermatology Service Conference. Update on Multidisciplinary Melanoma Care 8/5/99 Rex Healthcare Obstetric and Gynecology Grand Rounds. Breast Cancer Screening: From Mammograms to Genetic Screening 9/24/98 Dermatology Service Conference. Sentinel Node Biopsies in Staging of Melanoma 4/98 Head and Neck Conference. Use of Sentinel Node Technology in Head and Neck Malignancies of Melanoma 1/98 Gynecologic Oncology Grand Rounds. Sentinel Lymph Nodes and Gynecologic Malignancies 3/13/97 Dermatology Service Conference. Sentinel Node Biopsies in Staging 1997 CPC Conference, Medicine Department. Gastric Volvulus Continuing Education Lectures: 02/06/09 New Hanover Regional Medical Center, Wilmington AHEC Program. Primary Liver Neoplasms and Non Colorectal Metastases 12/06/2007 New Hanover Regional Medical Center, Wilmington AHEC Program. Metastatic Colorectal Carcinoma 05/04/07 New Hanover Regional Medical Center, Wilmington AHEC Program. Management of advanced Rectal Carcinoma 07-06 Wake Hospital Surgery rounds: Recurrent Rectal Carcinoma. 12/01/04 Nash General Hospital Oncology Rounds ACHE Program: Diagnosis and Treatment of Thyroid Neoplasms. 01/07/02 Rex Oncology Conference. Multidisciplinary Treatment of Hepatic Metastases. 10/26/00 University of North Carolina at Chapel Hill School of Nursing, Symposium on Primary Care Management of Common Gastrointestinal Disorders in Adults. Current Therapies and Future Directions in the Treatment of Colorectal Cancers. 10/18/00 Cape Fear Valley Medical Center, Fayetteville, NC, Tumor Board Conference. Management of Pancreatic Neoplasms. 3/8/00 Western Wake Hospital, CME Conference, Wake AHEC Program. 1/21/98 Cape Fear Valley Medical Center, Fayetteville, NC, Tumor Board Conference. Low Rectal Cancer Management. Treatment Modalities for Hepatic Metastases 11/24/97 Randolph Hospital, Asheboro, NC. Overview of Diagnosis, Staging and reatment of Melanoma. 2/96 Wake Medical Center, Wake AHEC Program. Colorectal Cancer and HNPCC Syndrome. 8/95 Cape Fear Valley Medical Center, Fayetteville, NC, Tumor Board Conference. Management of Breast Neoplasms. 11/93 New Hanover Regional Medical Center, Wilmington AHEC Program. Grants Funded: Current Award: 2-T32-CA09688-12 NCI Surgical Oncology T32 Training Grant 08/01/08 07/30/13 Principal Investigators: Albert S. Baldwin and Benjamin F. Calvo This Surgical Oncology Training Program is designed to attract and train physicians with a clinical background in surgery in a two-year fellowship of basic oncological research Prior Award: 2-T32-CA09688 NCI-Surgical Oncology Research Training Program. This Surgical Oncology Training Program is designed to attract and train physicians with a clinical background in surgery in a two-year fellowship of basic oncological research. $108,376.00, Benjamn Calvo, MD 2% 4/1/02-3/31/07 1-P50-CA106991 NIH SPORE in Gastrointestinal Cancer Project 3 To decrease the burden of colorectal cancer on the patient population at large. Benjamn Calvo, MD 10% 8/1/04-2/28/09 CA058223-AV-47P2-NCI-AVON-A phase II trial of OSI-774 (Tarceva) a HER(erbB) tyrosine kinase inhibitor in treatment Nave operable breast cancer. Benjamin Calvo, MD 07/04- NIH/NCI 5-P50 CA58223-09A1 SPORE in Breast Cancer Project 6: Breast Tumor Molecular Profiling Using cDNA Microarrays(Charles Perou, PhD-25%, $177,057.00, Benjamin Calvo, MD-10%) 8/1/01-7/1/06 3-R01-CA066519 NCI. The Effect of Cytotoxic Therapy on Inducing Lytic Epstein-Barr Virus in EBV-Associated Malignancy Supplement $69,428.00, Benjamn Calvo, MD 0.00% 10/1/03-9/30/04 Lineberger Comprehensive Cancer Center Research Award A Biologic study of the early effects of chemotherapy and radiotherapy on global gene expression, NF-kappa B and p53 in adenocarcinoma of the rectum. Benjamin Calvo P.I 7/02 Lineberger Comprehensive Cancer Center Clinical Research Award Role of the Ras-related oncoprotein, TC 21/R-Ras 2, in Human Colorectal Carcinomas Benjamin Calvo, P.I., 3/1/95-2/29/96, $10,000. Involvement: Principal Investigator responsible for molecular biology experiments. NIH/ NCI 5 R25 CA17973-21, Cancer Education Program, Benjamin Calvo, P.I., 9/30/95-11/30/99, $553,065 Involvement: Planning and execution of assistantship program. Recruit faculty to serve as mentors in research assistantship. Recruit and organize faculty for Core Seminar. Coordinate program evaluation with Dr. Stritter. Direct the Committee on Minority Cancer Education and serve as liaison with minority Hispanic networks. IRB Protocols: Institutional Investigator: EGF 10004: Safety, Pharmacokinetic and Pharmacodynamic Study of Multiple Doses of GW572016 to Examine the Inhibition of EGFR/erB-2 Phosphorylation in Cancer Patients with Solid Tumors. LCCC 9614: Gamma Probe-Guided Biopsy of the Sentinel Lymph Node in Malignant Melanoma. LCCC 9733: A Multicenter Trial of Adjuvant Interferon alfa-2b for Melanoma Patients with Early Lymph Node Metastasis Detected by Lymphatic Mapping and Sentinel Lymph Node Biopsy IRB# 97-SURG 36 ORC CYT103: Intravenously Administered 111In-Satumomab Pendetide in the Detection of Metastatic Breast Carcinoma. IRB 01-MED-542-ORC GI Database Professional Societies: 2010-present International Society of Intraoperative Radiation Therapy (ISIORT) 2000-present American Society of Clinical Oncology (ASCO) 1993-present Fellow, American College of Surgeons (ACS) 1997-2001 American Association for Cancer Education (AACE) 1997-present American Association for Cancer Research (AACR) 1996-present American Association for the Advancement of Science (AAAS) 1995-present Inter-American College of Physicians and Surgeons 1994-2011 Cancer and Leukemia Group B (CALGB) 1994-present Womack Medical Society 1993-present Lineberger Comprehensive Cancer Center, UNC 1992-present Society of Surgical Oncology (SSO) Professional Societies Honorary: 2010 Bolivian Cancer Society Honorary Member Professional Service: 2003-present Chief, Division of Surgical Oncology and Endocrine Surgery, UNC-CH 2001-present Director, Gastro-Intestinal Multidisciplinary Oncology Program UNC-CH 1997-1999 Principal Investigator and Director Cancer Education Program UNC-CH. 1997- 2000 Director of Multidisciplinary Melanoma Program UNC-CH. 1994- 1999 Director of the Cancer Education Program UNC-CH. 1994- present Member, UNC Lineberger Comprehensive Cancer Center. 1994 - 2002 Member of the Multidisciplinary Breast Cancer Program. Medical Director of Boat Clinic, Mamore and Itenez Rivers, Amazon Basin, Bolivia Reviewer (Ad hoc): Clinical Cancer Research, International Journal of Cancer, North Carolina Biotechnology Center Professional Services: National Committees: 2011- ASCO Membership Committee. 2007 CALGB Correlative Sciences Committee. 2003- 2006 Society of Surgical Oncology Membership Committee. 2003 Associate Examiner for the American Board of Surgery, Raleigh Durham. 2002-2004 American College of Surgeons Commission on Cancer. Disease Site Team on Upper G.I. Cancer National Cancer Data Base (NCDB). 2002- 2007 Society of Surgical Oncology Training Committee. ACOSOG (American College of Surgeons Oncology Group) Basic Science & Correlative Studies Comm. 1996-1998 Cancer and Leukemia Group B (CALGB) GI Committee, Cadre member. State Committees: 1994 - 1999 Cancer Committee, North Carolina Chapter of the American College of Surgeons University of North Carolina School of Medicine: 2008- present Center for Latino Health (CELAH) Advisory Board 2007- present UNC Palliative Care Advisory Board 2008 University Cancer Research Fund (UCRF) grant review (January 08) 2006 Radiation Oncology Chair search committee 2005- 2007 Lineberger Cancer Center Clinical Translational Grants Review Panel 2005 School of Medicine Strategic Plan. Research task force 2004 Medical School Translational Research Committee: Chair Dr. Charles Jennette 2004 Committee for the Evaluation of Dr. Charles Jennette, Chair Dept. of Pathology 2003-present North Carolina Clinical Cancer Center Oncology Advisory Council 2001-present Advisory Committee to the Center for Health Ethics and Policy. Advisory Committee to the Laparoscopic Institute of North Carolina Medical Faculty Grants Committee reviewer UNC P&A Clinical Information Systems Advisory Committee Student Research Advisory Committee Department of Surgery Strategic Planning Clinical Practice Subcommittee Other Administrative Activities: 1997-2000 Section of Surgical Oncology. Computer Systems Creation, Organization and Administration 1993-2005 Multidisciplinary GI and Sarcoma Tumor Conference. Creation, organization and oversight. 1993-2003 Surgical Oncology Medical Student Clerkship Organization and student Evaluations. OTHER Visiting Professorships or Lectureships: 1st International Biennial of Oncology A.C. Camargo Hospital and the congress of the Brazilian Society of Surgical Oncology. Sao Paolo, Brazil May 12-14 2011. Invited professor IOERT in the treatment of locally advanced and recurrent colorectal carcinoma The Epidermal Growth Factor Receptor and Ligand families in Colorectal Carcinomas Panel on The Training of Surgical Oncologists. XXIII National Science Congress of the Peruvian Medical Student Society. Nov 5, 2009 invited professor. Current state of advanced tumor ablation techniques. From benchtop to bedside, translational research of EGFR receptor and ligand family. SJTU School Of Medicine, Ruijin Hospital, Shanghai, China. October 14-15, 2009 IOERT in the treatment of locally advanced and recurrent colorectal carcinoma The role of IOERT in early breast carcinoma. The role of IOERT in retroperitoneal and limb sarcomas. Cancer Hospital of Fudan University Medical School, Shanghai, China. October 12-13, 2009 IOERT in the treatment of locally advanced and recurrent colorectal carcinoma The role of IOERT in early breast carcinoma. The role of IOERT in retroperitoneal and limb sarcomas. National Institute of Cancer, Bogota, Colombia. Use of intra operative electron radiation therapy (IOERT) in the treatment of advanced and recurrent rectal cancer. August 3,4, 2009. Catholic University of Bolivia San Pablo Visiting Professor. Pelvic exenteration for recurrent rectal cancer. Hepatic resections for colorectal metastases. July 13, 2009. George Washington University Department of Surgery. The Paul Shorb Lectureship. Paradigm Shifts and a career in Surgical Oncology. May 6th, 2009. Chinese Academy of Sciences Hospital and Institute; Department of Surgery and Radiation Oncology. Beijing China. Intra Operative Radiation Therapy (IOERT) in the treatment of advanced and recurrent rectal cancer. October 13-16 2008. Peoples Liberation Army Hospital; Dep. of Surgery and Radiation Oncology. Beijing China. Intra operative radiation therapy in the treatment of advanced and recurrent rectal cancer. October 18 2008 Trinity College Dublin. Department of Surgery ErbB family Receptors and Ligands in colorectal cancer September 9-11 2006 Instituto Oncologico del Oriente, Santa Cruz, Bolivia, Update Course Aspectos Basicos de la Colo-Proctologia. Sphincter preservation for rectal cancer. Surgical treatment of hepatic metastases. October 13-17, 1999 Instituto Medico, Sucre, Bolivia, Genetics and cancer: Introduction to general principles. Genetic predisposition to colorectal cancer. September 3, 1998 Instituto Oncologico del Oriente, Santa Cruz, Bolivia, Update Course, August 27-29 1998 Oncology applications for monoclonal antibodies. Multimodality therapy for treatment of rectal cancer. Genetics and cancer: introduction to general principles.     PAGE 13 Calvo, B.F. 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